MyBioSource.com's Anti-Hu STAT1 (pS727) Purified is a Mouse monoclonal antibody. The Anti-Hu STAT1 (pS727) Purified Antibody was generated using STAT1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation